So I was wondering, since pretty much all of the mainstream gaming mice out there only support USB 2, has anyone else had these weird sorts of issues with generally plugging in USB 2 devices into USB 3 ports? Does anyone purposely plug their mouse into a USB 2 port because that is what it natively supports? I couldn't site any sources, but from what I understand having a device that is native USB 2 plugged into a USB 2 port has lower latency and less overhead on the information sent to and from the device. Been perfect ever since, and I've since tested that same original USB 3 port with other USB 3 devices and it's worked just fine. The fix? Moving it from the many USB 3 ports on my x99 Deluxe to the only USB 2 port in the rear IO.

I ran into a curious issue with my Corsair M95 where it would randomly stop responding (lights would go off and back on in about half a second), and when it was responding the button assignments I had setup in the mouse software outputted seemingly random characters (set up a button to hit 1, would output 5).

Color of usb 2 vs usb 3